The age-dependent induction of apoptosis-inducing factor (AIF) in the human semitendinosus skeletal muscle

@article{Park2009TheAI,
  title={The age-dependent induction of apoptosis-inducing factor (AIF) in the human semitendinosus skeletal muscle},
  author={Soo Yeon Park and Ha Young Kim and Jung Hwan Lee and Kyoung Ho Yoon and Mun Seog Chang and Seong Kyu Park},
  journal={Cellular & Molecular Biology Letters},
  year={2009},
  volume={15},
  pages={1-12}
}
To assess the dependence on age of the expression of apoptosis regulatory proteins in the human semitendinosus muscle, we measured the expression levels of several apoptosis-related genes, including apoptosis-inducing factor (AIF), Bax, Bcl-2, caspase-3 and heat shock protein 70 (HSP70), using RT-PCR, immunohistochemistry and TUNEL assays. We found that the DNA fragmentation was proportional to the age of the tissues sample donors. The expression levels of AIF were significantly elevated (by 10… CONTINUE READING
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