The age and evolution of an antiviral resistance mutation in Drosophila melanogaster

@article{Bangham2007TheAA,
  title={The age and evolution of an antiviral resistance mutation in Drosophila melanogaster},
  author={Jenny Bangham and Darren J Obbard and Kang-Wook Kim and Penelope R. Haddrill and Francis M. Jiggins},
  journal={Proceedings of the Royal Society B: Biological Sciences},
  year={2007},
  volume={274},
  pages={2027 - 2034}
}
What selective processes underlie the evolution of parasites and their hosts? Arms-race models propose that new host-resistance mutations or parasite counter-adaptations arise and sweep to fixation. Frequency-dependent models propose that selection favours pathogens adapted to the most common host genotypes, conferring an advantage to rare host genotypes. Distinguishing between these models is empirically difficult. The maintenance of disease-resistance polymorphisms has been studied in detail… CONTINUE READING
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