The age and evolution of an antiviral resistance mutation in Drosophila melanogaster

  title={The age and evolution of an antiviral resistance mutation in Drosophila melanogaster},
  author={Jenny Bangham and Darren J Obbard and Kang-Wook Kim and Penelope R. Haddrill and Francis M. Jiggins},
  journal={Proceedings of the Royal Society B: Biological Sciences},
  pages={2027 - 2034}
What selective processes underlie the evolution of parasites and their hosts? Arms-race models propose that new host-resistance mutations or parasite counter-adaptations arise and sweep to fixation. Frequency-dependent models propose that selection favours pathogens adapted to the most common host genotypes, conferring an advantage to rare host genotypes. Distinguishing between these models is empirically difficult. The maintenance of disease-resistance polymorphisms has been studied in detail… CONTINUE READING
Highly Cited
This paper has 53 citations. REVIEW CITATIONS

From This Paper

Topics from this paper.


Publications citing this paper.
Showing 1-10 of 29 extracted citations

No more non-model species: the promise of next generation sequencing for comparative immunology.

Developmental and comparative immunology • 2014
View 3 Excerpts
Highly Influenced

54 Citations

Citations per Year
Semantic Scholar estimates that this publication has 54 citations based on the available data.

See our FAQ for additional information.


Publications referenced by this paper.
Showing 1-10 of 36 references

Contamine , D . 1980 Two types of early mutants among the temperature sensitive mutants of Drosophila sigma virus

M. Ashburner, T. R. F. Wright
Ann . Virol . • 2007

Similar Papers

Loading similar papers…