The afterload-dependent peak efficiency of the isolated working rat heart is unaffected by streptozotocin-induced diabetes

@inproceedings{Han2014TheAP,
  title={The afterload-dependent peak efficiency of the isolated working rat heart is unaffected by streptozotocin-induced diabetes},
  author={June-Chiew Han and Soyeon Goo and Carolyn J. Barrett and Kimberley M Mellor and Andrew James Taberner and Denis Scott Loiselle},
  booktitle={Cardiovascular diabetology},
  year={2014}
}
BACKGROUND Diabetes is known to alter the energy metabolism of the heart. Thus, it may be expected to affect the efficiency of contraction (i.e., the ratio of mechanical work output to metabolic energy input). The literature on the subject is conflicting. The majority of studies have reported a reduction of myocardial efficiency of the diabetic heart, yet a number of studies have returned a null effect. We propose that these discrepant findings can be reconciled by examining the dependence of… CONTINUE READING
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