The affinity of (−)-propranolol for β 1- and β 1-autoreceptors of human heart

@article{Gille1985TheAO,
  title={The affinity of (−)-propranolol for β 1- and β 1-autoreceptors of human heart},
  author={Esther Gille and Horst Lemoine and Bernhard Ehle and Alberto Julio Kaumann},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  year={1985},
  volume={331},
  pages={60-70}
}
An appraisal of the affinity of (−)-propranolol was made for β-adrenoceptors of isolated heart preparations and myocardial membrane particles from patients undergoing open heart surgery. 1. In order to eliminate possible distorting influences of neuronal and extraneuronal uptakes of catecholamines on the affinity estimates for (−)-propranolol, isolated tissues were pretreated once with 5 or 10 μmol/l phenoxybenzamine for 2 h. Phenoxybenzamine caused potentiation of the positive inotropic… CONTINUE READING

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