The aetiologies of epilepsy.

@article{Balestrini2021TheAO,
  title={The aetiologies of epilepsy.},
  author={Simona Balestrini and Alexis Arzimanoglou and Ingmar Bl{\"u}mcke and Ingrid Eileen Scheffer and Samuel Wiebe and Johan Zelano and Matthew C. Walker},
  journal={Epileptic disorders : international epilepsy journal with videotape},
  year={2021},
  volume={23 1},
  pages={
          1-16
        }
}
The identification of the aetiology of a patient's epilepsy is instrumental in the diagnosis, prognostic counselling and management of the epilepsies. Indeed, the aetiology can be important for determining the recurrence risk of single seizures and so for making a diagnosis of epilepsy. Here, we divide the aetiologies into six categories: structural, genetic, infectious, metabolic, immune (all of which are part of the International League Against Epilepsy [ILAE] classification system) and… 

Figures and Tables from this paper

Governance of the clinical pathway and management of the patient suffering from epilepsy and drug-resistant epilepsy

It is of vital importance to define a specific governance model that has to be virtuously applied into the different phases of the clinical pathway of the patients with epilepsy in order to guarantee them the best model of care possible.

Intestinal Flora Composition Determines Microglia Activation and Improves Epileptic Episode Progress

Intestinal microorganisms influence the occurrence and development of epilepsy by regulating the polarization of microglia, and the research connections Int intestinal microorganisms, brain immune status, and epilepsy behavior together.

Molecular Mechanism and Regulation of Autophagy and Its Potential Role in Epilepsy

The historical landmarks and distinct types of autophagy, recent progress in the core machinery and regulation of autphagy, and biological roles of Autophagy in homeostatic maintenance of neuronal structures and functions are overviewed, with a particular focus on synaptic plasticity.

A structured, blended learning program towards proficiency in epileptology: the launch of the ILAE Academy Level 2 Program

The ILAE Academy is the online learning platform of the International League Against Epilepsy (ILAE) and offers a structured educational program addressing the competency-based ILAE curriculum in

Real-life survey of pitfalls and successes of precision medicine in genetic epilepsies

This systematic survey of patients with epilepsy with a molecular genetic diagnosis is conducted in six tertiary epilepsy centres and suggests the adoption of a more considered approach to precision medicine in epilepsy.

References

SHOWING 1-10 OF 98 REFERENCES

ILAE classification of the epilepsies: Position paper of the ILAE Commission for Classification and Terminology

The International League Against Epilepsy (ILAE) Classification of the Epilepsies has been updated to reflect our gain in understanding of the epilepsies and their underlying mechanisms following the

Infections, inflammation and epilepsy

The pathogenesis of epilepsy due to brain infections, as well as the role of experimental models to study mechanisms of epileptogenesis induced by infectious agents, is reviewed and autoimmune encephalitis as a cause of seizures is reviewed.

Treatment of Epileptic Encephalopathies.

There is evidence that tailored treatment could significantly improve epilepsy treatment and prognosis, and potentially effective tailored precision medicine strategies available for some of the encephalopathies, and therapies with currently unexplained effectiveness in others.

Epidemiology and aetiology of epilepsy in sub-Saharan Africa

ILAE Official Report: A practical clinical definition of epilepsy

A revised definition of epilepsy brings the term in concordance with common use for individuals who either had an age‐dependent epilepsy syndrome but are now past the applicable age or who have remained seizure‐free for the last 10 years and off antiseizure medicines for at least the last 5 years.

Epilepsy in patients with brain tumours: epidemiology, mechanisms, and management

Occasional seizures, epilepsy, and inborn errors of metabolism

Epilepsy in inborn errors of metabolism.

The main characteristics of epilepsy due to inborn errors of energy metabolism, to disturbed neuronal function due to accumulation of storage products, to toxic effects and to disturbed neurotransmitter systems are reviewed.
...