The advantages and disadvantages of running a clinical trial in general practices

  title={The advantages and disadvantages of running a clinical trial in general practices},
  author={C S Jones and Richard William Billington and Gavin J Pearson},
  journal={British Dental Journal},
This paper reviews the experiences encountered in running a clinical trial on the use of a metal reinforced glass-ionomer cement in general dental practices. The practitioners were asked to place both the test material and amalgam in the same patient and to take impressions both at placement and at three recall intervals. Subsequently plaster casts were produced from these impressions. These were then assessed by three independent observers to provide evaluation of the relative wear of the two… 

A clinical evaluation of all-ceramic bridges placed in UK general dental practices: first-year results

All the bridges examined at the first-year review were present, intact and performing well, though one small chip of the veneering porcelain was detected and in two cases an abutment tooth had been endodontically treated through an occlusal access cavity.

Obtaining an Evidence-Base for Clinical Dentistry through Clinical Trials

Suggestions are made for overcoming the challenge of patient recruitment in randomised controlled clinical trials in primary dental care, and use of the CONSORT statement to improve planning and reporting of clinical trials is recommended.

The Hall Technique; a randomized controlled clinical trial of a novel method of managing carious primary molars in general dental practice: acceptability of the technique and outcomes at 23 months

After two years, Hall PMCs showed more favourable outcomes for pulpal health and restoration longevity than conventional restorations, and appears to offer an effective treatment option for carious primary molar teeth.

The effect of at-home bleaching on the microhardness of six esthetic restorative materials

The perceived generalisability of a given guideline to general dental practice is as important as the evidence contained within it.

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The views of general dental practitioners (GDPs) in North Wales on the use of preformed metal crowns (PMCs) for the treatment of primary molars were determined to determine their approach to restorative care in children.

The views of dentists on their participation in a primary care-based research trial

Future research in primary care should be focused on topics primary care practitioners feel of use to their clinical practice, and a method of funding practitioners and providing time for them to complete research away from their clinical duties is necessary.

Primary care research: views of a dental team on their experiences of a primary care study

The authors of this article contend that research in primary care should not only be promoted, but that indeed it should be routine in nature, and that funding should be partially directed towards primary dental care research in order to ensure this.

Practical considerations for conducting dental clinical trials in primary care

Examination of five dental clinical trials across both Australia and the UK and the various factors that impacted upon their implementation suggest that early stakeholder engagement, and well-designed and managed trials, lead to improved outcomes for researchers, clinic staff and patients, and increases the potential for future dissemination and translation of information into practice.

A Pilot Study Evaluating Dental Research Enrollment in Four Multicenter Clinical Research Trials

When the managers of a periodontal clinical trial experienced a large gap between the projected number and the actual number of enrolled subjects within a planned time period, successful completion

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Reasons for placement and replacement of restorations of direct restorative materials by a selected group of practitioners in the United Kingdom.

It was found that about 60% of restorative practice in the United Kingdom may be found to comprise the replacement of existing restorations, and the principal reason for replacement was secondary caries.

Variation in powder/liquid ratio of a restorative glass-ionomer cement used in dental practice

This study investigates the powder/liquid ratios of a glass-ionomer restorative mixed in clinical practice and concludes that this restorative was often mixed in practice at much lower powder/ liquid ratios than that recommended by the manufacturer and that this would impair the cement's mechanical properties.

The comparative strengths of commercial glass-ionomer cements with and without metal additions

The addition of metal to glass-ionomer cements can markedly increase the strength of the materials, however, the method of fusing the metal to the glass rather than by simple addition does not produce any advantages in strength.

Effect of Abrasion Medium on Wear of Stress-bearing Composites and Amalgam in vitro

This preliminary study reports the results obtained with a fixed choice of contact stress, speed, and slip, but with different third-body media, which showed a wear pattern and relative ranking comparable with that reported in clinical studies.

Occlusal wear simulation with the ACTA wear machine.

A general dental practice research network — philosophy, activities and participant views

A group of primary dental care practitioners was recruited into a Primary Dental Network and the aim was to develop the practitioners' research interest into research skills and finally into a research project.

Early and Long-term Wear of Conventional and Resin-modified Glass Ionomers

It was concluded that none of these materials can yet be recommended for use in high-stress-bearing situations because of the unfavorable wear characteristics of the resin-modified glass ionomers and the high early wear of the conventional glass ionomer.

Vivadent comparison to M-L, Leinfelder, and USPHS clinical wear scales

  • J Dent Res (Special Issue)
  • 1990

The comparative strengths of glass-ionomer cements with and without metal additions

  • Br Dent J
  • 1992