The advance of Muller's ratchet in a haploid asexual population: approximate solutions based on diffusion theory.

@article{Stephan1993TheAO,
  title={The advance of Muller's ratchet in a haploid asexual population: approximate solutions based on diffusion theory.},
  author={Wolfgang Stephan and Lin Rui Chao and J G Smale},
  journal={Genetical research},
  year={1993},
  volume={61 3},
  pages={225-31}
}
Asexual populations experiencing random genetic drift can accumulate an increasing number of deleterious mutations, a process called Muller's ratchet. We present here diffusion approximations for the rate at which Muller's ratchet advances in asexual haploid populations. The most important parameter of this process is n0 = N e-U/s, where N is population size, U the genomic mutation rate and s the selection coefficient. In a very large population, n0 is the equilibrium size of the mutation-free… CONTINUE READING