The adrenergic system in pulmonary arterial hypertension: bench to bedside (2013 Grover Conference series).

In heart failure with reduced left ventricular ejection fraction (HFrEF), adrenergic activation is a key compensatory mechanism that is a major contributor to progressive ventricular remodeling and worsening of heart failure. Targeting the increased adrenergic activation with β-adrenergic receptor blocking agents has led to the development of arguably the… CONTINUE READING