The adipocyte and hemostatic balance in obesity: studies of PAI-1.

@article{Loskutoff1998TheAA,
  title={The adipocyte and hemostatic balance in obesity: studies of PAI-1.},
  author={David J. Loskutoff and Fahumiya Samad},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={1998},
  volume={18 1},
  pages={1-6}
}
P lasminogen activator inhibitor 1 is the primary physiological inhibitor of plasminogen activation in vivo, and elevations in plasma PAI-1 appear to compromise normal fibrin clearance mechanisms and promote thrombosis. PAI-1 is dramatically upregulated in obesity, a complex condition associated with increased risk for myocardial infarction, accelerated atherosclerosis, hypertension, glucose intolerance, insulin resistance, hyperinsulinemia, and NIDDM. In spite of the apparent link between… CONTINUE READING

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References

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Showing 1-10 of 42 references

Gene expression and function of plasminogen activator inhibitor-1

  • DA Lawrence, D. Ginsburg
  • 1996
Highly Influential
4 Excerpts

Augmentation of expression of plasminogen activator inhibitor type-1 in adipocytes and its potential role in acceleration of vasculopathy associated with obesity

  • T Sakamoto, J Woodcock-Mitchell, S Fuji, BE Sobel, DJ. Schneider
  • Circulation. 1997;96(suppl I):I-546. Abstract
  • 1997
1 Excerpt

Elevated PAI-1 and tissue factor gene expression in obese mice: a possible mechanism for the increased risk for cardiovascular disease associated with obesity

  • F Samad, M Pandey, V de Waard, DJ. Loskutoff
  • Fibrinol Proteol
  • 1997
1 Excerpt

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