The adipocyte and hemostatic balance in obesity: studies of PAI-1.

  title={The adipocyte and hemostatic balance in obesity: studies of PAI-1.},
  author={David J. Loskutoff and Fahumiya Samad},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  volume={18 1},
P lasminogen activator inhibitor 1 is the primary physiological inhibitor of plasminogen activation in vivo, and elevations in plasma PAI-1 appear to compromise normal fibrin clearance mechanisms and promote thrombosis. PAI-1 is dramatically upregulated in obesity, a complex condition associated with increased risk for myocardial infarction, accelerated atherosclerosis, hypertension, glucose intolerance, insulin resistance, hyperinsulinemia, and NIDDM. In spite of the apparent link between… CONTINUE READING


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