The adhesion receptor CD155 determines the magnitude of humoral immune responses against orally ingested antigens

@article{Maier2007TheAR,
  title={The adhesion receptor CD155 determines the magnitude of humoral immune responses against orally ingested antigens},
  author={Michael K. Maier and Sebastian Seth and Niklas Czeloth and Quan Qiu and Inga Ravens and Elisabeth Kremmer and Maria Ebel and Werner M{\"u}ller and Oliver Pabst and Reinhold F{\"o}rster and G{\"u}nter Bernhardt},
  journal={European Journal of Immunology},
  year={2007},
  volume={37}
}
CD155, originally known as the cellular receptor for poliovirus, is the founding member of a subfamily of immunoglobulin‐like adhesion receptors. Apart from its function in establishing adherens junctions between contacting epithelial cells, the engagement of CD155 with two recently identified ligands, CD226 and CD96, mediates immunologically relevant processes such as NK cell‐driven killing of tumor cells in humans. Here we report on the generation and immunological analysis of mice… 

The murine pan T cell marker CD96 is an adhesion receptor for CD155 and nectin-1.

Abundance of follicular helper T cells in Peyer's patches is modulated by CD155

TLDR
Mice deficient for CD155, an adhesion receptor of the immunoglobulin superfamily, are impaired to mount a secondary humoral immune response upon oral administration of antigen, while the primary IgM response is unaffected.

The receptors CD96 and CD226 oppose each other in the regulation of natural killer cell functions

TLDR
It is found that CD96 competed with CD226 for CD155 binding and limited NK cell function by direct inhibition, and mice displayed hyperinflammatory responses to the bacterial product lipopolysaccharide (LPS) and resistance to carcinogenesis and experimental lung metastases.

Intranodal Interaction with Dendritic Cells Dynamically Regulates Surface Expression of the Co-stimulatory Receptor CD226 Protein on Murine T Cells*

TLDR
It is demonstrated that DCs are capable of manipulating CD226 levels on T cells in vivo but not in vitro, suggesting that the process of T cells actively scanning antigen-presenting DCs inside secondary lymphoid organs is required for CD226 modulation.

Heterogeneous expression of the adhesion receptor CD226 on murine NK and T cells and its function in NK‐mediated killing of immature dendritic cells

TLDR
CD226 is the first mNK receptor identified to be essential for the elimination of this particular cell type and established mAb specifically recognizing mCD226, demonstrating that CD226 is expressed by precursor and mature but not developing T cells.

CD96 Interaction with CD155 via Its First Ig-like Domain Is Modulated by Alternative Splicing or Mutations in Distal Ig-like Domains*

TLDR
Using chimeric human/murine CD96 receptors, it is shown that the interaction with its ligands is mediated via the outermost V-like domain, and that a CD96-driven adhesion to CD155 may be crucial in developmental processes.

CD155/CD226‐interaction impacts on the generation of innate CD8+ thymocytes by regulating iNKT‐cell differentiation

TLDR
It is shown that absence of either CD155 or CD226 in BALB/c mice causes a profound shift in the iNKT subtype composition in thymus, expanding the frequency and numbers of iN KT1 cells at the expense ofiNKT2 cells, as well as iNkt17 cells.

Increased CD112 Expression in Methylcholanthrene-Induced Tumors in CD155-Deficient Mice

TLDR
Results suggest that modulation of the expression of receptors and CD112 compensates for CD155 deficiency in immune surveillance against MCA-induced tumors.

Regulates Allergic Inflammation T Cells and + Costimulatory Signal in CD4 CD155 (PVR/Necl5) Mediates a

TLDR
CD155 plays an important regulatory role in helper T cell differentiation and allergic diseases and induced Th1 development in both humans and mice, as evidenced by production of IFN- g and upregulation of Tbx21 transcription.

A novel molecular interaction for the adhesion of follicular CD4 T cells to follicular DC

TLDR
A novel immunoreceptor is described, expressed on human follicular B helper T cells (TFH) and binds a Nectin/Necl family member, the poliovirus receptor (PVR), under both static and flow conditions and it is demonstrated that PVR is abundantly expressed by follicular DC (FDC) within the germinal center.
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