The adhesion of Plasmodium falciparum-infected erythrocytes to chondroitin sulfate A is mediated by P. falciparum erythrocyte membrane protein 1.

@article{Reeder1999TheAO,
  title={The adhesion of Plasmodium falciparum-infected erythrocytes to chondroitin sulfate A is mediated by P. falciparum erythrocyte membrane protein 1.},
  author={John C. Reeder and Alan F Cowman and Kathy M. Davern and James G Beeson and Jennifer K. Thompson and Stephen J Rogerson and Graham V. Brown},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1999},
  volume={96 9},
  pages={5198-202}
}
Chondroitin sulfate A (CSA) is an important receptor for the sequestration of Plasmodium falciparum in the placenta, but the parasite ligand involved in adhesion has not previously been identified. Here we report the identification of a var gene transcribed in association with binding to CSA and present evidence that the P. falciparum erythrocyte membrane protein 1 product of the gene is the parasite ligand mediating CSA binding. Description of this gene and the implication of P. falciparum… CONTINUE READING
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