The adhesion force of Notch with Delta and the rate of Notch signaling

@article{Ahimou2004TheAF,
  title={The adhesion force of Notch with Delta and the rate of Notch signaling},
  author={Francois Ahimou and L. Mok and Boris Bardot and Cedric S. Wesley},
  journal={The Journal of Cell Biology},
  year={2004},
  volume={167},
  pages={1217 - 1229}
}
Notch signaling is repeatedly used during animal development to specify cell fates. Using atomic force microscopy on live cells, chemical inhibitors, and conventional analyses, we show that the rate of Notch signaling is linked to the adhesion force between cells expressing Notch receptors and Delta ligand. Both the Notch extracellular and intracellular domains are required for the high adhesion force with Delta. This high adhesion force is lost within minutes, primarily due to the action of… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 46 REFERENCES

Furin cleavage is not a requirement for Drosophila Notch function

  • Mechanisms of Development
  • 2002
VIEW 12 EXCERPTS
HIGHLY INFLUENTIAL

Antibody recognition imaging by force microscopy

Peter Hinterdorfer, Anneliese Raab, +4 authors Hansgeorg Schindler
  • Nature Biotechnology
  • 1999
VIEW 1 EXCERPT
HIGHLY INFLUENTIAL