The adherence of platelets to adsorbed albumin by receptor-mediated recognition of binding sites exposed by adsorption-induced unfolding.

@article{Sivaraman2010TheAO,
  title={The adherence of platelets to adsorbed albumin by receptor-mediated recognition of binding sites exposed by adsorption-induced unfolding.},
  author={Balakrishnan Sivaraman and Robert A. Latour},
  journal={Biomaterials},
  year={2010},
  volume={31 6},
  pages={1036-44}
}
Although albumin (Alb) is the most abundant plasma protein, it is considered to be non-adhesive to platelets, as it lacks any known amino acid sequences for binding platelet receptors. Recent studies have suggested that platelets adhere to adsorbed Alb by mechanisms linked to its conformational state. To definitively address this issue we used circular dichroism (CD) spectropolarimetry to characterize the conformation of Alb adsorbed on a broad range of surface chemistries from a wide range of… CONTINUE READING
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Investigationof theeffects of surface chemistry and solution concentration on the conformation of adsorbed proteins using an improved circular dichroism method

  • FearsKP SivaramanB, LatourRA
  • Langmuir
  • 2009

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