The adenovirus type 5 E1B-55K oncoprotein actively shuttles in virus-infected cells, whereas transport of E4orf6 is mediated by a CRM1-independent mechanism.

@article{Dosch2001TheAT,
  title={The adenovirus type 5 E1B-55K oncoprotein actively shuttles in virus-infected cells, whereas transport of E4orf6 is mediated by a CRM1-independent mechanism.},
  author={T Dosch and Friedemann Horn and Grit Schneider and Friedrich Kr{\"a}tzer and Thomas Dobner and Joachim Hauber and Roland H. Stauber},
  journal={Journal of virology},
  year={2001},
  volume={75 12},
  pages={5677-83}
}
The E1B-55K and E4orf6 proteins of adenovirus type 5 are involved in viral mRNA export. Here we demonstrate that adenovirus infection does not inhibit the function of the E1B-55K nuclear export signal and that E1B-55K also shuttles in infected cells. Even during virus infection, E1B-55K was exported by the leptomycin B-sensitive CRM1 pathway, whereas E4orf6 transport appeared to be mediated by an alternative mechanism. Our results strengthen the potential role of E1B-55K as the "driving force… CONTINUE READING

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The adenovirus type 5 E 1 B – 55 K oncoprotein is a highly active shuttle protein and shuttling is independent of E 4 orf 6 , p 53 and Mdm 2

B. Wolff, T. Sekimoto, +4 authors M. Yoshida
Oncogene • 2000

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