The adenovirus protein Gam1 interferes with sumoylation of histone deacetylase 1.

@article{Colombo2002TheAP,
  title={The adenovirus protein Gam1 interferes with sumoylation of histone deacetylase 1.},
  author={Riccardo Colombo and Roberto Boggio and Christian Seiser and Giulio F Draetta and Susanna Chiocca},
  journal={EMBO reports},
  year={2002},
  volume={3 11},
  pages={1062-8}
}
The adenovirus early gene product Gam1 is crucial for virus replication and induces certain cellular genes by inactivating histone deacetylase 1 (HDAC1). We demonstrate that Gam1 (i) destroys promyelocitic leukemia nuclear bodies, (ii) delocalizes SUMO-1 into the cytoplasm and (iii) influences the SUMO-1 pathway. In addition, we show that Gam1 counteracts HDAC1 sumoylation both in vivo and in vitro. Sumoylation of HDAC1 does not seem to be absolutely required for HDAC1 biological activity but… CONTINUE READING