The adenovirus e1a-associated p300 protein is differentially phosphorylated in ad12 e1a-compared to ad5 e1a-transformed rat-cells.

Abstract

Recently, using hybrid Ad5/12 E1A-transformed rat cells, we identified at least two regions of Ad12 E1A which influence tumorigenicity. In this report, again using the hybrid Ad5/12 E1A-transformants, we show that expression of these same two Ad12 E1A regions not only correlates with down-regulation of cell surface MHC class I expression, but coincides with… (More)

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