The adenovirus E1A repression domain disrupts the interaction between the TATA binding protein and the TATA box in a manner reversible by TFIIB.

@article{Song1997TheAE,
  title={The adenovirus E1A repression domain disrupts the interaction between the TATA binding protein and the TATA box in a manner reversible by TFIIB.},
  author={Chen Zhao Song and Paul M. Loewenstein and Katalin Toth and Q. Q. Tang and Atsushi Nishikawa and Michael C. Green},
  journal={Molecular and cellular biology},
  year={1997},
  volume={17 4},
  pages={2186-93}
}
The human adenovirus E1A 243 amino acid oncoprotein possesses a transcription repression function that appears to be linked with its ability to induce cell cycle progression and to inhibit cell differentiation. The molecular mechanism of E1A repression has been poorly understood. Recently, we reported that the TATA binding protein (TBP) is a cellular target of E1A repression. Here we demonstrate that the interaction between TBP and the E1A repression domain is direct and specific. The TBP… CONTINUE READING

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