The adenosine A2A receptor interacts with the actin-binding protein alpha-actinin.

@article{Burgueo2003TheAA,
  title={The adenosine A2A receptor interacts with the actin-binding protein alpha-actinin.},
  author={Javier Burgue{\~n}o and Derek J Blake and Matthew Arnold Benson and Caroline L. Tinsley and Christopher T. Esapa and Enric I. Canela and Petronila Penela and Josefa Mallol and Federico Mayor and Carmen Lluis and Rafael Franco and Francisco Ciruela},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 39},
  pages={
          37545-52
        }
}
Recently, evidence has emerged that heptaspanning membrane or G protein-coupled receptors may be linked to intracellular proteins identified as regulators of receptor anchoring and signaling. Using a yeast two-hybrid screen, we identified alpha-actinin, a major F-actin-cross-linking protein, as a binding partner for the C-terminal domain of the adenosine A2A receptor (A2AR). Colocalization, co-immunoprecipitation, and pull-down experiments showed a close and specific interaction between A2AR… CONTINUE READING

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