The adenosine 2b receptor is recruited to the plasma membrane and associates with E3KARP and Ezrin upon agonist stimulation.

@article{Sitaraman2002TheA2,
  title={The adenosine 2b receptor is recruited to the plasma membrane and associates with E3KARP and Ezrin upon agonist stimulation.},
  author={Shanthi V. Sitaraman and Lixin Wang and Michelle Wong and Matthias Bruewer and Michael E. Hobert and C Yun and Didier Merlin and James L. Madara},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 36},
  pages={33188-95}
}
We have previously shown that adenosine is formed in the intestinal lumen during active inflammation from neutrophil-derived 5'-AMP. Acting through the adenosine A2b receptor (A2bR), the luminally derived adenosine induces vectorial chloride secretion and a polarized secretion of interleukin-6 to the intestinal lumen. Although some G protein-coupled receptors interact with anchoring or signaling molecules, not much is known in this critical area for the A2bR. We used the model intestinal… CONTINUE READING
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The Adenosine 2b Receptor Is Recruited and Associates with E3KARP 33195 by gest on Jne 28

  • J. Cheng, B. D. Moyer, +7 authors W. B. Guggino
  • J. Biol. Chem
  • 2002

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