The adenine nucleotide translocator in apoptosis.

  title={The adenine nucleotide translocator in apoptosis.},
  author={A S Belzacq and Helena L A Vieira and Guido Kroemer and Catherine Brenner},
  volume={84 2-3},
Alteration of mitochondrial membrane permeability is a central mechanism leading invariably to cell death, which results, at least in part, from the opening of the permeability transition pore complex (PTPC). Indeed, extended PTPC opening is sufficient to trigger an increase in mitochondrial membrane permeability and apoptosis. Among the various PTPC components, the adenine nucleotide translocator (ANT) appears to act as a bi-functional protein which, on the one hand, contributes to a crucial… CONTINUE READING
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