The adenine nucleotide translocase type 1 (ANT1): a new factor in mitochondrial disease.

@article{Sharer2005TheAN,
  title={The adenine nucleotide translocase type 1 (ANT1): a new factor in mitochondrial disease.},
  author={Jon Daniel Sharer},
  journal={IUBMB life},
  year={2005},
  volume={57 9},
  pages={607-14}
}
Mitochondrial disorders of oxidative phosphorylation (OXPHOS) comprise a growing list of potentially lethal diseases caused by mutations in either mitochondrial (mtDNA) or nuclear DNA (nDNA). Two such conditions, autosomal dominant progressive external ophthalmoplegia (adPEO) and Senger's Syndrome, are associated with dysfunction of the heart and muscle-specific isoform of the adenine nucleotide translocase (ANT1), a nDNA gene product that facilitates transport of ATP and ADP across the inner… CONTINUE READING