The additive genetic gamma frailty model for linkage analysis of age-of-onset variation.

@article{Li1999TheAG,
  title={The additive genetic gamma frailty model for linkage analysis of age-of-onset variation.},
  author={Hongzhe Li},
  journal={Annals of human genetics},
  year={1999},
  volume={63 Pt 5},
  pages={455-68}
}
  • Hongzhe Li
  • Published 1999 in Annals of human genetics
Age of onset is a key factor in the linkage analysis of many complex diseases. Current methods in nonparametric linkage analysis are mainly concentrated on the affected relative pairs or affected family members with age of onset information either ignored or taken into account by specifying age-dependent penetrances for liability classes. On the other hand, gamma frailty models were developed in the biostatistics literature to model familial aggregation of age of onset. However, these frailty… CONTINUE READING

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E-mail: hli@ucdavis

E-mail: hli@ucdavis

Running title: Gamma frailty model for linkage analysis Address correspondence to: Hongzhe Li

Running title: Gamma frailty model for linkage analysis Address correspondence to: Hongzhe Li

The additive genetic gamma frailty model for linkage analysis of age-of-onset variation H

The additive genetic gamma frailty model for linkage analysis of age-of-onset variation H

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