The additive effects of minoxidil and retinol on human hair growth in vitro.

  title={The additive effects of minoxidil and retinol on human hair growth in vitro.},
  author={Hyeon Gyeong Yoo and In-Young Chang and Hyun Keol Pyo and Yong Jung Kang and Seung Ho Lee and Oh Sang Kwon and Kwang Hyun Cho and Hee Chul Eun and Kyu Han Kim},
  journal={Biological \& pharmaceutical bulletin},
  volume={30 1},
Minoxidil enhances hair growth by prolonging the anagen phase and induces new hair growth in androgenetic alopecia (AGA), whereas retinol significantly improves scalp skin condition and promotes hair growth. [] Key Method We investigated the combined effects of minoxidil and retinol on human hair growth in vitro and on cultured human dermal papilla cells (DPCs) and epidermal keratinocytes (HaCaT). The combination of minoxidil and retinol additively promoted hair growth in hair follicle organ cultures. In…

Figures from this paper

In vitro Hair Growth Promoting Effects of Naringenin and Hesperetin on Human Dermal Papilla Cells and Keratinocytes

The preliminary results obtained here suggest the hair growth promoting properties of Naringenin and Hesperetin, presenting them as potential candidates for natural hair-growth promoting compositions.

In vivo and In vitro hair growth promotion effects of extract from Glycine soja Siebold et Zucc

The GSSZ extract promoted hair growth and increased hair growth-related cell activity, and could therefore be utilized in alopecia treatment.

Review of Hair Follicle Dermal Papilla cells as in vitro screening model for hair growth

The pivotal role of DPCs in the forefront of hair research as screening platforms is highlighted by providing insights into mechanistic action at cellular level, which may further direct the development of novel hair growth modulators.

Hair Growth Promoting Potential of Phospholipids Purified from Porcine Lung Tissues

Collectively, BP201 possesses hair growth promoting potential, which would suggest its use singly or in combination for hair growth products.

Effects of all-trans retinoic acid on goat dermal papilla cells cultured in vitro

Serenoa repens extracts promote hair regeneration and repair of hair loss mouse models by activating TGF-β and mitochondrial signaling pathway.

LSESr promoted the hair regeneration and repair of hair loss mouse models by activating TGF-β signaling and mitochondrial signaling pathway.

Effect of Vitex rotundifolia on Hair Regeneration : in vitro and in vivo study

Treatment of Vitex rotundifolia extract onto hair cells induced more 20% growth of proliferation compared only control treated group, and the ratio of follicle number of anagen phase/total was increased, which explains that ViteX rotund ifolia extract has effect on prolong ofAnagen phase, so Vitez rotundIfolia might be a potential new therapeutic source for the hair growth promotion.

Tretinoin enhances minoxidil response in androgenetic alopecia patients by upregulating follicular sulfotransferase enzymes

This is the first study to elucidate the interaction mechanism between topical minoxidil and retinoids and thus provides a pathway for the development of future androgenetic alopecia treatments.

Minoxidil Downregulates Interleukin-1 Alpha Gene Expression in HaCaT Cells

This anti-inflammatory effect of minoxidil, as evidenced by significant downregulation of IL-1α gene expression in HaCaT cells, may represent one of its mechanisms of action in alopecia.



Topical tretinoin for hair growth promotion.

Retinoids: compounds important to hair growth.

Minoxidil: mechanisms of action on hair growth

The current state of knowledge on the mode of action of minoxidil on hair growth is reviewed, and lines of future research are indicated that may be relevant to hair growth.

Hair follicle biology and topical minoxidil: possible mechanisms of action.

It is concluded that the most probable site for the action of minoxidil is on the specialized mesenchymal cells of the follicular dermal papilla.

Minoxidil upregulates the expression of vascular endothelial growth factor in human hair dermal papilla cells

Two studies support the hypothesis that minoxidil has a physiological role in maintaining a good vascularization of hair follicles in androgenetic alopecia and VEGF protein production increases in cell extracts and conditioned media following minxidil stimulation.

Inhibitory effects of bFGF, VEGF and minoxidil on collagen synthesis by cultured hair dermal papilla cells

The results suggest that both culture substrate and growth factors influence collagen production by rat hair dermal papilla cells, with Quantification of total collagen by incorporation of3H-proline in monolayer cultures and in collagen lattices show that the amount of collagen found in dermal Papa cells is higher than that secreted.

Human hair growth in vitro.

The importance of this model to hair follicle biology is demonstrated by the observations that TGF-beta 1 has a negative growth-regulatory effect on hair follicles in vitro and that EGF mimics the in vivo depilatory effects that have been reported in sheep and mice.

Minoxidil stimulates mouse vibrissae follicles in organ culture.

These studies demonstrate that organ cultured follicles are suitable for determining minoxidil's mechanism of action and may be useful for studying other aspects of hair biology and suggest that minoxil's action in vivo includes more than just increasing blood flow to hair follicles.