The additionally glycosylated variant of human sex hormone‐binding globulin (SHBG) is linked to estrogen‐dependence of breast cancer

@article{Becchis1999TheAG,
  title={The additionally glycosylated variant of human sex hormone‐binding globulin (SHBG) is linked to estrogen‐dependence of breast cancer},
  author={Marzia Becchis and Roberto Frairia and P. Garc{\'i}a Ferrera and Annamaria Fazzari and Sabrina Ondei and Alda Alfarano and Claudio Coluccia and Nicoletta Biglia and Piero Sismondi and Nicoletta Fortunati},
  journal={Breast Cancer Research and Treatment},
  year={1999},
  volume={54},
  pages={101-107}
}
Sex Hormone‐Binding Globulin (SHBG), the plasma carrier for androgens and estradiol, inhibits the estradiol‐induced proliferation of breast cancer cells through its membrane receptor, cAMP, and PKA. In addition, the SHBG membrane receptor is preferentially expressed in estrogen‐dependent (ER+/PR+) breast cancers which are also characterized by a lower proliferative rate than tumors negative for the SHBG receptor. A variant SHBG with a point mutation in exon 8, causing an aminoacid substitution… CONTINUE READING
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Molecular mechanisms of the D327N SHBG protective role on breast cancer development after estrogen exposure

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