The addition of 7.5% glucose does not alter the neurotoxicity of 5% lidocaine administered intrathecally in the rat.

@article{Sakura1995TheAO,
  title={The addition of 7.5% glucose does not alter the neurotoxicity of 5% lidocaine administered intrathecally in the rat.},
  author={Shinichi Sakura and Vincent W.S. Chan and R Ciriales and Kenneth Drasner},
  journal={Anesthesiology},
  year={1995},
  volume={82 1},
  pages={236-40}
}
BACKGROUND Recent reports of major and minor neurologic sequelae after spinal anesthesia have generated concern regarding the safety of some currently used intrathecal agents. The role of glucose, if any, in neurotoxic injury associated with spinal anesthesia is not known. The current experiments sought to determine whether the presence of 7.5% glucose alters the neurotoxicity of intrathecally administered 5% lidocaine. METHODS Two experiments were performed. First, 48 rats were implanted… CONTINUE READING

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Effects of glucose administered with lidocaine solution on spinal neurotoxicity in rats.

International journal of clinical and experimental medicine • 2015
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ARTIGO CIENTÍFICO Efeitos neurotóxicos de levobupivacaína e fentanil sobre a medula espinhal de ratos Yesim

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