The added value of impedance-pH monitoring to Rome III criteria in distinguishing functional heartburn from non-erosive reflux disease.

@article{Marabotto2011TheAV,
  title={The added value of impedance-pH monitoring to Rome III criteria in distinguishing functional heartburn from non-erosive reflux disease.},
  author={Elisa Marabotto and Patrizia Zentilin and Marzio Frazzoni and Giorgio Sammito and Daria Bonfanti and Luca Maria Sconfienza and Lorenzo Assandri and Lorenzo Gemignani and Alberto Malesci and Vincenzo Savarino},
  journal={Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver},
  year={2011},
  volume={43 7},
  pages={
          542-7
        }
}
INTRODUCTION Functional heartburn is defined by Rome III criteria as an endoscopy-negative condition with normal oesophageal acid exposure time, negative symptom association to acid reflux and unsatisfactory response to proton pump inhibitors. These criteria underestimated the role of non-acid reflux. AIM To assess the contribution of impedance-pH with symptom association probability (SAP) analysis in identifying endoscopy-negative patients with reflux disease and separating them from… CONTINUE READING
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