The added value of PMS2 immunostaining in the diagnosis of hereditary nonpolyposis colorectal cancer

@article{Halvarsson2006TheAV,
  title={The added value of PMS2 immunostaining in the diagnosis of hereditary nonpolyposis colorectal cancer},
  author={Britta Halvarsson and A. Arto Lindblom and Eva Rambech and Kristina Lagerstedt and Mef Nilbert},
  journal={Familial Cancer},
  year={2006},
  volume={5},
  pages={353-358}
}
Identification and characterization of the genetic background in patients with the hereditary nonpolyposis colorectal cancer (HNPCC) syndrome is important since control programmes can in a cost-effective manner prevent cancer development in high-risk individuals. HNPCC is caused by germline mismatch repair (MMR) gene mutations and the genetic analysis of HNPCC therefore includes assessment of microsatellite instability (MSI) and immunohistochemical MMR protein expression in the tumor tissue… CONTINUE READING

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