The adaptor protein soc-1/Gab1 modifies growth factor receptor output in Caenorhabditis elegans.

@article{Hopper2006TheAP,
  title={The adaptor protein soc-1/Gab1 modifies growth factor receptor output in Caenorhabditis elegans.},
  author={Neil A. Hopper},
  journal={Genetics},
  year={2006},
  volume={173 1},
  pages={163-75}
}
Previous genetic analysis has shown that dos/soc-1/Gab1 functions positively in receptor tyrosine kinase (RTK)-stimulated Ras/Map kinase signaling through the recruitment of csw/ptp-2/Shp2. Using sensitized assays in Caenorhabditis elegans for let-23/Egfr and daf-2/InsR (insulin receptor-like) signaling, it is shown that soc-1/Gab1 inhibits phospholipase C-gamma (PLCgamma) and phosphatidylinositol 3'-kinase (PI3K)-mediated signaling. Furthermore, as well as stimulating Ras/Map kinase signaling… CONTINUE READING
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