The adaptor protein Bam32 regulates Rac1 activation and actin remodeling through a phosphorylation-dependent mechanism.

@article{Allam2004TheAP,
  title={The adaptor protein Bam32 regulates Rac1 activation and actin remodeling through a phosphorylation-dependent mechanism.},
  author={Atef Allam and Hiroaki Niiro and Edward A. Clark and Aaron J Marshall},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 38},
  pages={39775-82}
}
The B cell adaptor molecule of 32 kDa (Bam32) is an adaptor that links the B cell antigen receptor (BCR) to ERK and JNK activation and ultimately to mitogenesis. After BCR cross-linking, Bam32 is recruited to the plasma membrane and accumulates within F-actin-rich membrane ruffles. Bam32 contains one Src homology 2 and one pleckstrin homology domain and is phosphorylated at a single site, tyrosine 139. To define the function of Bam32 in membrane-proximal signaling events, we established human B… CONTINUE READING
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  • A. V. Miletic, M. Swat, K. Fujikawa, W. Swat
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