The adaptor protein AMOT promotes the proliferation of mammary epithelial cells via the prolonged activation of the extracellular signal-regulated kinases.

@article{Ranahan2011TheAP,
  title={The adaptor protein AMOT promotes the proliferation of mammary epithelial cells via the prolonged activation of the extracellular signal-regulated kinases.},
  author={William P Ranahan and Zhang Liwen Han and Whitney R. Smith-Kinnaman and Sarah C. Nabinger and Brigitte L Heller and Britney-Shea Herbert and Rebecca Y Chan and Clark D. Wells},
  journal={Cancer research},
  year={2011},
  volume={71 6},
  pages={2203-11}
}
The asymmetric organization of epithelial cells is a basic counter to cellular proliferation. However, the mechanisms whereby pro-growth pathways are modulated by intracellular factors that control cell shape are not well understood. This study demonstrates that the adaptor protein Amot, in addition to its established role in regulating cellular asymmetry, also promotes extracellular signal-regulated kinase 1 and 2 (ERK1/2)-dependent proliferation of mammary cells. Specifically, expression of… CONTINUE READING

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