The adaptive responses in several mediators linked with hypertrophy and atrophy of skeletal muscle after lower limb unloading in humans.

@article{Sakuma2009TheAR,
  title={The adaptive responses in several mediators linked with hypertrophy and atrophy of skeletal muscle after lower limb unloading in humans.},
  author={Kunihiro Sakuma and Kouichi Watanabe and Norio Hotta and Teruhiko Koike and Keiko Ishida and Keisho Katayama and Hiroshi Akima},
  journal={Acta physiologica},
  year={2009},
  volume={197 2},
  pages={151-9}
}
AIM To determine the adaptive changes in several molecules regulating muscle hypertrophy and atrophy after unloading, we examined whether unilateral lower limb suspension changes the mRNA and protein levels of SRF-linked (RhoA, RhoGDI, STARS and SRF), myostatin-linked (myostatin, Smad2, Smad3 and FLRG) and Foxo-linked (P-Akt, Foxo1, Foxo3a and Atrogin-1) mediators. METHODS A single lower limb of each of eight healthy men was suspended for 20 days. Biopsy specimens were obtained from the… CONTINUE READING
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