The adaptive changes in the isoenzyme pattern of myosin from hypertrophied rat myocardium as a result of pressure overload and physical training

@article{Rupp1981TheAC,
  title={The adaptive changes in the isoenzyme pattern of myosin from hypertrophied rat myocardium as a result of pressure overload and physical training},
  author={Dr. H. Rupp},
  journal={Basic Research in Cardiology},
  year={1981},
  volume={76},
  pages={79-88}
}
The distribution of cardiac myosin isoenzymes is altered as a result of pressure overload and physical training. Using polyacrylamide gel electrophoresis in sodium pyrophosphate, it was found that myosin fromlleft ventricles of adult rats exists in three polymorphic form, V1, V2 and V3. Cardiac hypertrophy due to renal hypertension (Goldblatt II) led to a shift of the isoenzymes towards V3, whereas swimming training resulted in an opposite redistribution. The isoenzyme V1 predominated, only… CONTINUE READING
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