The adapter protein Shc couples a class of integrins to the control of the cell cycle

@inproceedings{Giancotti1999TheAP,
  title={The adapter protein Shc couples a class of integrins to the control of the cell cycle},
  author={Filippo Giancotti and Kishore K Wary and Fabrizio Mainiero},
  year={1999}
}
For properembryonic development andtissue homeo- integrins with Shc, mediated by caveolin-1 and Fyn, isstasis, cell proliferation must be regulated spatially and necessary and sufficient to activate the Ras-Erk signalingtemporally. In particular, a cell must be able to sense its pathway. In contrast, activation of focal adhesion kinaserelationship to other cells and the extracellular matrix does not cause this event. Although ligation of integrinsand convert these positional cues into… CONTINUE READING

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