The acylation mechanism of CTX-M beta-lactamase at 0.88 a resolution.

Abstract

â-Lactamases are the most widespread cause of bacterial resistance to the â-lactam antibiotics, such as the penicillins and cephalosporins, and the mechanisms of these enzymes are intensely studied. For the class A â-lactamases, such as TEM, SHV, and the newly emergent extended-spectrum â-lactamase (ESBL) CTX-M enzymes,1 X-ray structures have been… (More)

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Cite this paper

@article{Chen2007TheAM, title={The acylation mechanism of CTX-M beta-lactamase at 0.88 a resolution.}, author={Yu Chen and Richard Bonnet and Brian K. Shoichet}, journal={Journal of the American Chemical Society}, year={2007}, volume={129 17}, pages={5378-80} }