The acyl-CoA binding protein is required for normal epidermal barrier function in mice.

@article{Bloksgaard2012TheAB,
  title={The acyl-CoA binding protein is required for normal epidermal barrier function in mice.},
  author={Maria Bloksgaard and Signe Bek and Ann-Britt Marcher and Ditte Neess and Jonathan R. Brewer and Hans Kristian Hannibal-Bach and Torben Helledie and Christina Fenger and Marianne Due and Zane Berzina and Reinhard H. H. Neubert and John Chemnitz and Bente Finsen and Anders Clemmensen and Johannes H Wilbertz and Henrik Saxtorph and Jens Knudsen and Luis A. Bagatolli and S Mandrup},
  journal={Journal of lipid research},
  year={2012},
  volume={53 10},
  pages={2162-74}
}
The acyl-CoA binding protein (ACBP) is a 10 kDa intracellular protein expressed in all eukaryotic species. Mice with targeted disruption of Acbp (ACBP(-/-) mice) are viable and fertile but present a visible skin and fur phenotype characterized by greasy fur and development of alopecia and scaling with age. Morphology and development of skin and appendages are normal in ACBP(-/-) mice; however, the stratum corneum display altered biophysical properties with reduced proton activity and decreased… CONTINUE READING

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Furthermore , skin and fur sebum monoalkyl diacylglycerol ( MADAG ) levels are significantly increased , suggesting that ACBP limits MADAG synthesis in sebaceous glands .
Furthermore , skin and fur sebum monoalkyl diacylglycerol ( MADAG ) levels are significantly increased , suggesting that ACBP limits MADAG synthesis in sebaceous glands .
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