The acyclic nucleoside phosphonates (ANPs): Antonín Holý's legacy.


The name of Antonín Holý has become synonymous for the era of acyclic nucleoside phosphonates (ANPs), which started with (S)-HPMPA as the prototype and (S)-HPMPC (cidofovir) as the first marketed compound. It has now evolved to a number of compounds clinically used in the treatment of HIV and hepatitis B virus infections, either as such [tenofovir… (More)
DOI: 10.1002/med.21283


Cite this paper

@article{Clercq2013TheAN, title={The acyclic nucleoside phosphonates (ANPs): Anton{\'i}n Hol{\'y}'s legacy.}, author={Erik De Clercq}, journal={Medicinal research reviews}, year={2013}, volume={33 6}, pages={1278-303} }