The acute splanchnic and peripheral tissue metabolic response to endotoxin in humans.

@article{Fong1990TheAS,
  title={The acute splanchnic and peripheral tissue metabolic response to endotoxin in humans.},
  author={Yin Mei Fong and Michael A. Marano and Lyle L. Moldawer and H Wei and Steve E. Calvano and John S. Kenney and Anthony C. Allison and Anthony Cerami and G. Tom Shires and Stephen F. Lowry},
  journal={The Journal of clinical investigation},
  year={1990},
  volume={85 6},
  pages={
          1896-904
        }
}
The in vivo alterations in organ-specific substrate processing and endogenous mediator production induced by endotoxin were investigated in healthy volunteers. An endotoxin bolus (20 U/kg) produced increased energy expenditure, hyperglycemia, hypoaminoacidemia, and an increase in circulating free fatty acids. These changes included increased peripheral lactate and free fatty acid output, along with increased peripheral uptake of glucose. Coordinately, there were increased splanchnic uptake of… Expand
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