The acute-phase response of the liver in relation to thyroid hormone-induced redox signaling.

@article{Tapia2006TheAR,
  title={The acute-phase response of the liver in relation to thyroid hormone-induced redox signaling.},
  author={Gladys S Tapia and V icente Mart inez de Vega Fernandez and Cesar Pino and Rodrigo Ardiles and Luis A Videla},
  journal={Free radical biology & medicine},
  year={2006},
  volume={40 9},
  pages={1628-35}
}
Recently, we reported that 3,3',5-triiodothyronine (T3) induces the expression of redox-sensitive genes as a nongenomic mechanism of T3 action. In this study, we show that T3 administration to rats (daily doses of 0.1 mg/kg ip for 3 consecutive days) induced a calorigenic response and liver glutathione depletion as an indication of oxidative stress, with higher levels of interleukin (IL)-6 in serum (ELISA) and hepatic STAT3 DNA binding (EMSA), which were maximal at 48-72 h after treatment… CONTINUE READING

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