The acute light-induction of sleep is mediated by OPN4-based photoreception

  title={The acute light-induction of sleep is mediated by OPN4-based photoreception},
  author={Daniela Lupi and Henrik Oster and Stewart Thompson and Russell G. Foster},
  journal={Nature Neuroscience},
Sleep is regulated by both homeostatic and circadian mechanisms. The latter, termed 'process c', helps synchronize sleep-wake patterns to the appropriate time of the day. However, in the absence of a circadian clock, overall sleep-wake rhythmicity is preserved and remains synchronized to the external light-dark cycle, indicating that there is an additional, clock-independent photic input to sleep. We found that the direct photic regulation of sleep in mice is predominantly mediated by… 

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