The acute effects of kava and oxazepam on anxiety, mood, neurocognition; and genetic correlates: a randomized, placebo‐controlled, double‐blind study
@article{Sarris2012TheAE, title={The acute effects of kava and oxazepam on anxiety, mood, neurocognition; and genetic correlates: a randomized, placebo‐controlled, double‐blind study}, author={Jerome Sarris and Andrew Scholey and Isaac Schweitzer and Chad A. Bousman and E Laporte and Chee H. Ng and Greg Murray and Con Stough}, journal={Human Psychopharmacology: Clinical and Experimental}, year={2012}, volume={27} }
Kava (Piper methysticum) is a psychotropic plant medicine with history of cultural and medicinal use. We conducted a study comparing the acute neurocognitive, anxiolytic, and thymoleptic effects of a medicinal dose of kava to a benzodiazepine and explored for the first time specific genetic polymorphisms, which may affect the psychotropic activity of phytomedicines or benzodiazepines.
22 Citations
Kava in the Treatment of Generalized Anxiety Disorder: A Double-Blind, Randomized, Placebo-Controlled Study
- PsychologyJournal of clinical psychopharmacology
- 2013
Standardized kava may be a moderately effective short-term option for the treatment of generalized anxiety disorder (GAD), and specific GABA transporter polymorphisms appear to potentially modify anxiolytic response to kava.
Does a Medicinal Dose of Kava Impair Driving? A Randomized, Placebo-Controlled, Double-Blind Study
- MedicineTraffic injury prevention
- 2013
A medicinal dose of kava containing 180 mg of kavalactones does not impair driving ability, whereas 30 mg of oxazepam shows some impairment, and research assessing larger recreational doses of kva on driving ability should now be conducted.
The Pharmacology, Pharmacokinetics, Efficacy, and Adverse Events Associated With Kava
- MedicineJournal of clinical pharmacology
- 2018
Kava is a plant with numerous kavapyrones that can induce pharmacologic effects and drug interactions through the cytochrome P450 and P‐glycoprotein systems. Kava is used recreationally and for the…
Herbal Anxiolytics with Sedative Actions
- Biology
- 2017
This chapter will present evidence from human clinical trials regarding the efficacy of herbal treatments with a primarily sedative mode of action for chronic (everyday) supplementation to address anxiety symptoms.
Kava for the treatment of generalised anxiety disorder (K-GAD): study protocol for a randomised controlled trial
- PsychologyTrials
- 2015
If this study demonstrates positive findings in support of the superiority of kava over placebo in the treatment of GAD, and also is shown to be safe, then this plant-medicine can be considered a ’first-line‘ therapy for GAD.
Oxazepam for the Treatment of Substance Abuse and Depression: Is it Appropriate?
- Psychology, MedicineJournal of psychosocial nursing and mental health services
- 2016
Oxazepam is potentially useful in the treatment of substance abuse, especially in conjunction with the cortisol synthesis inhibitor metyrapone, and can be considered an appropriate medication to use in thereatment of depression.
Kava decreases the stereotyped behavior induced by amphetamine in mice.
- Psychology, BiologyJournal of ethnopharmacology
- 2020
Kava for Generalized Anxiety Disorder: A Review of Current Evidence.
- Psychology, MedicineJournal of alternative and complementary medicine
- 2018
Current evidence, although promising, is insufficient to confirm the effect of Kava for GAD treatment beyond placebo, and new evidence is expected from a large, multisite ongoing trial.
Herbal medicine for depression and anxiety: A systematic review with assessment of potential psycho‐oncologic relevance
- MedicinePhytotherapy research : PTR
- 2018
Black cohosh, chamomile, chasteberry, lavender, passionflower, and saffron appear useful in mitigating anxiety or depression with favorable risk–benefit profiles compared to standard treatments, which may benefit cancer patients by minimizing medication load and accompanying side effects.
Plant-Based Medicines for Anxiety Disorders, Part 2: A Review of Clinical Studies with Supporting Preclinical Evidence
- PsychologyCNS Drugs
- 2013
A comprehensive narrative review of plant-based medicines that have clinical and/or preclinical evidence of anxiolytic activity and conclusions need to be tempered due to methodological issues such as small sample sizes, brief intervention durations and non-replication.
References
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