The acute effect of the bioprecursor of the selective brain MAO-A inhibitor, MDL 72392, on rat pineal melatonin biosynthesis.

@article{Oxenkrug1994TheAE,
  title={The acute effect of the bioprecursor of the selective brain MAO-A inhibitor, MDL 72392, on rat pineal melatonin biosynthesis.},
  author={G. Oxenkrug and P. Requintina and A. Yuwiler and M. Palfreyman},
  journal={Journal of neural transmission. Supplementum},
  year={1994},
  volume={41},
  pages={
          377-9
        }
}
  • G. Oxenkrug, P. Requintina, +1 author M. Palfreyman
  • Published 1994
  • Chemistry, Medicine
  • Journal of neural transmission. Supplementum
  • The bioprecursor amino acid MDL 72394 is decarboxylated by aromatic L-amino acid decarboxylase (AADC) to liberate MDL 72392, an irreversible selective MAO-A inhibitor. Pretreatment with the AADC inhibitor carbidopa, which does not penetrate the brain-blood barrier, prevents the liberation of the MAO-A inhibitor outside the brain and results in exclusive inhibition of brain MAO-A. We found that systemic administration of MDL 72394 (0.5 mg/kg, i.p.) stimulated rat pineal melatonin biosynthesis… CONTINUE READING
    3 Citations