The acute effect of high dose corticosteroid treatment on serum osteocalcin.

@article{Ekenstam1988TheAE,
  title={The acute effect of high dose corticosteroid treatment on serum osteocalcin.},
  author={E A Ekenstam and Gunilla St{\aa}lenheim and Roger H{\"a}llgren},
  journal={Metabolism: clinical and experimental},
  year={1988},
  volume={37 2},
  pages={141-4}
}
Osteocalcin is a vitamin K-dependent protein that is synthesized by osteoblasts and present in circulation. We measured serum osteocalcin concentrations in nine asthmatics before and during treatment with high IV dosages of glucocorticoids, betamethasone 0.65 mg/h. This treatment induced within 13 +/- 1.5 (SEM) hours a reduction of serum osteocalcin form 2.6 +/- 0.3 (SEM) to 1.2 +/- 0.3 microgram/L (P less than .001). During the following 24-hour period the osteocalcin levels further declined… CONTINUE READING