The acute effect of fludrocortisone on basal and hCRH-stimulated hypothalamic–pituitary–adrenal (HPA) axis in humans

  title={The acute effect of fludrocortisone on basal and hCRH-stimulated hypothalamic–pituitary–adrenal (HPA) axis in humans},
  author={I. Karamouzis and R. Berardelli and E. Marinazzo and V. D’Angelo and Domenico Zinn{\`a} and M. Minetto and Clizia Zichi and B. Fussotto and R. Giordano and E. Ghigo and E. Arvat},
  • I. Karamouzis, R. Berardelli, +8 authors E. Arvat
  • Published 2012
  • Medicine
  • Pituitary
  • Mineralocorticoid receptors (MR) in the hippocampus display an important role in the control of hypothalamic–pituitary–adrenal (HPA)-axis, mediating the “proactive”-feedback of glucocorticoids. Fludrocortisone (FC), a potent MR agonist, has been shown to decrease HPA activity through a mechanism placed at hippocampal level. In order to clarify the effects of MR agonism on HPA function in humans, we studied the effects of FC, in a dose-related manner, on both basal and CRH-stimulated HPA axis… CONTINUE READING
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