The activity of the immunoregulatory enzyme indoleamine 2,3-dioxygenase is decreased in smokers.

@article{Pertovaara2006TheAO,
  title={The activity of the immunoregulatory enzyme indoleamine 2,3-dioxygenase is decreased in smokers.},
  author={Marja I Pertovaara and Markku Heli{\"o}vaara and Annika Raitala and S. S. Oja and Paul Knekt and Mikko A. Hurme},
  journal={Clinical and experimental immunology},
  year={2006},
  volume={145 3},
  pages={469-73}
}
Indoleamine 2,3-dioxygenase (IDO), an enzyme involved in the degradation of the essential amino acid tryptophan (trp) to its main metabolite kynurenine (kyn), suppresses T cell activity. Smoking has marked immunomodulatory effects, above all immunosuppressive, causing a reduction in the levels of immunoglobulins and an increased risk of infections. The immunostimulatory effects of smoking are manifested, for example, in increased autoantibody production. We sought to establish whether IDO… CONTINUE READING

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