The activity of hsp90α promoter is regulated by NF-κB transcription factors

  title={The activity of hsp90α promoter is regulated by NF-κB transcription factors},
  author={Massimo Ammirante and Alessandra Rosati and Antonio Gentilella and Michela Festa and Antonello Petrella and Liberato Marzullo and Mar{\'i}a Laura Pascale and Maria Antonietta Belisario and Alvaro Pascual Leone and Maria Caterina Turco},
Heat-shock proteins (HSP) 90 exert a relevant role in the survival and response to therapy of many neoplastic cell types. Here, we show that the promoter of hsp90α gene, that encodes the inducible form of HSP90, is regulated by nuclear factor-κB (NF-κB) activity. Indeed, we found that NF-κB factors bound to one of the two putative consensus sequences present in the hsp90α-flanking region; mutation of such motif hampered the phorbol-myristate-13-acetate-stimulated expression of a luciferase… CONTINUE READING
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