The activity of dispiro peroxides against Fasciola hepatica.

  title={The activity of dispiro peroxides against Fasciola hepatica.},
  author={Xiaofang Wang and Qingjie Zhao and M. Garc{\'i}a Vargas and Yuxiang Dong and Kamaraj Sriraghavan and Jennifer Keiser and Jonathan L. Vennerstrom},
  journal={Bioorganic & medicinal chemistry letters},
  volume={21 18},
Dispiro 1,2,4-trioxanes and 1,2,4,5-tetraoxanes had superior efficacy against Fasciola hepatica than the corresponding ozonides (1,2,4-trioxolanes). For highest efficacy, spiroadamantane and carboxymethyl substructures were required. Three compounds completely cured F. hepatica-infected mice at single oral doses of 50mg/kg and two were partially curative at single doses of 25mg/kg.