The activity of a novel mithramycin analog is related to its binding to DNA, cellular accumulation, and inhibition of Sp1-driven gene transcription.

@article{FernndezGuizn2014TheAO,
  title={The activity of a novel mithramycin analog is related to its binding to DNA, cellular accumulation, and inhibition of Sp1-driven gene transcription.},
  author={A. Fern{\'a}ndez-Guiz{\'a}n and Sylvia Mansilla and F. Barcel{\'o} and C. Vizca{\'i}no and L. N{\'u}{\~n}ez and F. Mor{\'i}s and S. Gonz{\'a}lez and J. Portugal},
  journal={Chemico-biological interactions},
  year={2014},
  volume={219},
  pages={
          123-32
        }
}
DIG-MSK (demycarosyl-3D-β-D-digitoxosyl-mithramycin SK) is a recently isolated compound of the mithramycin family of antitumor antibiotics, which includes mithramycin A (MTA) and mithramycin SK (MSK). Here, we present evidence that the binding of DIG-MSK to DNA shares the general features of other mithramycins such as the preference for C/G-rich tracts, but there are some differences in the strength of binding and the DNA sequence preferentially recognized by DIG-MSK. We aimed at gaining… Expand
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