The activity of 5'-nucleotidase in liver plasma membranes is affected by the increase in bilayer fluidity achieved by anionic drugs but not by cationic drugs.


The 5'-nucleotidase activity of rat liver plasma membranes could be selectively modulated by the anionic drugs phenobarbital and pentobarbital, whereas the corresponding activity of a Lubrol-solubilized preparations remained unaltered. The perturbation in the outer half of the bilayer induced by phenobarbital, which lead to a depression in the high… (More)


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