The activity-dependent histone variant H2BE modulates the life span of olfactory neurons

@inproceedings{Santoro2012TheAH,
  title={The activity-dependent histone variant H2BE modulates the life span of olfactory neurons},
  author={Stephen W. Santoro and C. Capdevielle Dulac},
  booktitle={eLife},
  year={2012}
}
We have identified a replication-independent histone variant, Hist2h2be (referred to herein as H2be), which is expressed exclusively by olfactory chemosensory neurons. Levels of H2BE are heterogeneous among olfactory neurons, but stereotyped according to the identity of the co-expressed olfactory receptor (OR). Gain- and loss-of-function experiments demonstrate that changes in H2be expression affect olfactory function and OR representation in the adult olfactory epithelium. We show that H2BE… CONTINUE READING
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