The activity and signaling range of mature BMP-4 is regulated by sequential cleavage at two sites within the prodomain of the precursor.

@article{Cui2001TheAA,
  title={The activity and signaling range of mature BMP-4 is regulated by sequential cleavage at two sites within the prodomain of the precursor.},
  author={Y B Cui and Ren{\'e}e Hackenmiller and Leslie J Berg and François Jean and Takao Nakayama and Gary Thomas and Jan L Christian},
  journal={Genes & development},
  year={2001},
  volume={15 21},
  pages={2797-802}
}
Proteolytic maturation of proBMP-4 is required to generate an active signaling molecule. We show that proBMP-4 is cleaved by furin in a sequential manner. Cleavage at a consensus furin site adjacent to the mature ligand domain allows for subsequent cleavage at an upstream nonconsensus furin site within the prodomain. BMP-4 synthesized from precursor in which the upstream site is noncleavable is less active, signals at a shorter range, and accumulates at lower levels than does BMP-4 cleaved from… CONTINUE READING

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